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Zerumbone Elevates Phase II, but not Phase I, Xenobiotic-Metabolizing Enzymes in Mouse Liver
https://cis.repo.nii.ac.jp/records/306
https://cis.repo.nii.ac.jp/records/3068f852fb3-0827-4234-9187-a6ee421631f3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
P011-020-Keiko SASAKI (337.8 kB)
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copyright (c) 2019 by Chiba Institute of Science
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-08-24 | |||||
| タイトル | ||||||
| タイトル | Zerumbone Elevates Phase II, but not Phase I, Xenobiotic-Metabolizing Enzymes in Mouse Liver | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
SASAKI, Keiko
× SASAKI, Keiko× WADA, Keiji× Kobayashi, Daisuke× MURAKAMI, Akira× MATUOKA, Koozi× SASAKI, Keiko× WADA, Keiji× Kobayashi, Daisuke× MURAKAMI, Akira× MATUOKA, Koozi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to characterize the biological actions of zerumbone (ZER), a cancer-suppressive component from rhizomes of Zingiber zerumbet Smith, its effects on the activities of various xenobiotic-metabolizing enzymes were analyzed. Mice were treated orally with ZER (10-100 mg/kg, once a day for 4 successive days) and then the enzyme activities in mouse organs were examined. Within the liver ZER increased glutathione S-transferase (GST) and quinone reductase (QR) activities in a dose-dependent manner up to 204% and 168% of the control, respectively. As the GST activation was most apparent with 1,2-dichloro-4- nitrobenzene as substrate, ZER seems to mainly induce the activity of class μ GST, which was supported by the result of a Western blotting experiment. In addition, contents of glutathione (reduced form) were slightly higher in the ZER-treated liver. Similarly, small intestine GST and QR activities elevated to 861% and 256% of the control, respectively, upon ZER treatment. In contrast, the activities of those enzymes fl uctuated little in kidney, lung or brain of ZER-treated mice. As for the phase I enzymes in the liver including cytochrome P450 and cytochrome b5; activities of 7-ethoxycoumarin O-deethylase, 7-methoxyresorufi n O-demethylase, 7-ethoxyresorufi n O-deethylase and 7-pentoxyresorufi n O-depentylase , ZER caused only marginal changes. Our study clearly indicated that ZER selectively activates phase II enzymes in the liver and small intestine, and thus can be considered to be a promising nutraceutical for cancer chemoprevention. |
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| 書誌情報 |
千葉科学大学紀要 en : The University Bulletin of Chiba Institute of Science 号 13, p. 11-20, 発行日 2020-02-28 |
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| 出版者 | ||||||
| 出版者 | 千葉科学大学 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1882-3505 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1230240X | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
