{"created":"2023-06-19T07:46:28.196699+00:00","id":306,"links":{},"metadata":{"_buckets":{"deposit":"3a2fd442-2f70-460f-84f1-17b2f2bbbf0e"},"_deposit":{"created_by":15,"id":"306","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"306"},"status":"published"},"_oai":{"id":"oai:cis.repo.nii.ac.jp:00000306","sets":["3:28"]},"author_link":["1014","1007","454","1040","1008","1011","1009","1013","1012","453"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageEnd":"20","bibliographicPageStart":"11","bibliographic_titles":[{"bibliographic_title":"千葉科学大学紀要"},{"bibliographic_title":"The University Bulletin of Chiba Institute of Science","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　In order to characterize the biological actions of zerumbone (ZER), a cancer-suppressive component\nfrom rhizomes of Zingiber zerumbet Smith, its effects on the activities of various xenobiotic-metabolizing\nenzymes were analyzed. Mice were treated orally with ZER (10-100 mg/kg, once a day for 4 successive\ndays) and then the enzyme activities in mouse organs were examined. Within the liver ZER increased\nglutathione S-transferase (GST) and quinone reductase (QR) activities in a dose-dependent manner up to\n204% and 168% of the control, respectively. As the GST activation was most apparent with 1,2-dichloro-4-\nnitrobenzene as substrate, ZER seems to mainly induce the activity of class μ GST, which was supported by\nthe result of a Western blotting experiment. In addition, contents of glutathione (reduced form) were slightly\nhigher in the ZER-treated liver. Similarly, small intestine GST and QR activities elevated to 861% and 256%\nof the control, respectively, upon ZER treatment. In contrast, the activities of those enzymes fl uctuated little\nin kidney, lung or brain of ZER-treated mice. As for the phase I enzymes in the liver including cytochrome\nP450 and cytochrome b5; activities of 7-ethoxycoumarin O-deethylase, 7-methoxyresorufi n O-demethylase,\n7-ethoxyresorufi n O-deethylase and 7-pentoxyresorufi n O-depentylase , ZER caused only marginal changes.\nOur study clearly indicated that ZER selectively activates phase II enzymes in the liver and small intestine, and\nthus can be considered to be a promising nutraceutical for cancer chemoprevention.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"千葉科学大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1230240X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1882-3505","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SASAKI, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"1011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WADA, Keiji"}],"nameIdentifiers":[{"nameIdentifier":"1012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"1013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MURAKAMI, Akira"}],"nameIdentifiers":[{"nameIdentifier":"1014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MATUOKA, Koozi"}],"nameIdentifiers":[{"nameIdentifier":"1040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SASAKI, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WADA, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Daisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MURAKAMI, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MATUOKA, Koozi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-20"}],"displaytype":"detail","filename":"P011-020-Keiko SASAKI.pdf","filesize":[{"value":"337.8 kB"}],"format":"application/pdf","license_note":"copyright (c) 2019 by Chiba Institute of Science","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"P011-020-Keiko SASAKI","url":"https://cis.repo.nii.ac.jp/record/306/files/P011-020-Keiko SASAKI.pdf"},"version_id":"898c3e1c-09a4-4f56-b902-f066a43e2c48"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Zerumbone Elevates Phase II, but not Phase I, Xenobiotic-Metabolizing Enzymes in Mouse Liver","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Zerumbone Elevates Phase II, but not Phase I, Xenobiotic-Metabolizing Enzymes in Mouse Liver"}]},"item_type_id":"10002","owner":"15","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-24"},"publish_date":"2020-08-24","publish_status":"0","recid":"306","relation_version_is_last":true,"title":["Zerumbone Elevates Phase II, but not Phase I, Xenobiotic-Metabolizing Enzymes in Mouse Liver"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T07:52:03.245709+00:00"}