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Pulegone and Piperitone, Essential Oil Components of Lamiaceae Family, Enhance the Activities of Drug-Metabolizing Enzymes
https://cis.repo.nii.ac.jp/records/412
https://cis.repo.nii.ac.jp/records/412886f5037-a0f5-4d7f-8e3f-4823c79d944c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
5-9佐々木啓子（英・原著） (616.4 kB)
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copyright (c) 2022 by Chiba Institute of Science
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-03-28 | |||||
| タイトル | ||||||
| タイトル | Pulegone and Piperitone, Essential Oil Components of Lamiaceae Family, Enhance the Activities of Drug-Metabolizing Enzymes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
SASAKI, Keiko
× SASAKI, Keiko× WADA, Keiji× MATUOKA, Koozi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of pulegone (PUL) and piperitone (PIP), monoterpene ketones found in the essential oils of Lamiaceae family, on the activities of phase I enzymes (7-ethoxyresorufin O-deethylase (EROD), 7-methoxyresorufin O-demethylase (MROD), and 7-pentoxyresorufin O-depentylase (PROD)) and phase II enzymes (glutathione S-transferase (GST) and quinone reductase (QR)) were investigated. Mice were treated orally with PUL (50-200 mg/kg), and PIP (50-200 mg/kg) once a day for 7 days, and then the hepatic and extrahepatic enzyme activities were analyzed. PUL (200 mg/kg) treatment resulted in significantly higher EROD, PROD, GST, and QR activities by 1.79-fold to 6.33-fold, and PIP (200 mg/kg) treatment caused significantly higher EROD, MROD, PROD, GST, and QR activities by 1.18-fold to 3.69-fold. Moreover, PUL-treated mice showed significantly higher protein levels of GST α and PIP-treated animals had significantly higher protein levels of GST π. Similarly, PUL treatment resulted in significantly higher GST and QR activities in kidney by 1.23-fold and 1.68-fold, respectively; PIP treatment caused significantly higher kidney QR activities by 1.32-fold. Additionally,PUL and PIP also caused higher lung QR activities by 1.24-fold and 1.54-fold, respectively. Taken together, we showed that PUL and PIP are bifunctional inducers, capable of inducing both the phase I and phase II enzymes in mice | |||||
| bibliographic_information |
千葉科学大学紀要 en : The University Bulletin of Chiba Insitute of Science 号 16, p. 5-9, 発行日 2023-03-28 |
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| 出版者 | ||||||
| 出版者 | 千葉科学大学 | |||||
| item_10002_source_id_9 | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2436-2565 | |||||
| item_10002_source_id_11 | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1230240X | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
