@article{oai:cis.repo.nii.ac.jp:00000412,
 author = {佐々木, 啓子 and SASAKI, Keiko and WADA, Keiji and MATUOKA, Koozi},
 issue = {16},
 journal = {千葉科学大学紀要, The University Bulletin of Chiba Insitute of Science},
 month = {Mar},
 note = {The effects of pulegone (PUL) and piperitone (PIP), monoterpene ketones found in the essential oils of Lamiaceae family, on the activities of phase I enzymes (7-ethoxyresorufin O-deethylase (EROD), 7-methoxyresorufin O-demethylase (MROD), and 7-pentoxyresorufin O-depentylase (PROD)) and phase II enzymes (glutathione S-transferase (GST) and quinone reductase (QR)) were investigated. Mice were treated orally with PUL (50-200 mg/kg), and PIP (50-200 mg/kg) once a day for 7 days, and then the hepatic and extrahepatic enzyme activities were analyzed. PUL (200 mg/kg) treatment resulted in significantly higher EROD, PROD, GST, and QR activities by 1.79-fold to 6.33-fold, and PIP (200 mg/kg) treatment caused significantly higher EROD, MROD, PROD, GST, and QR activities by 1.18-fold to 3.69-fold. Moreover, PUL-treated mice showed significantly higher protein levels of GST α and PIP-treated animals had significantly higher protein levels of GST π. Similarly, PUL treatment resulted in significantly higher GST and QR activities in kidney by 1.23-fold and 1.68-fold, respectively; PIP treatment caused significantly higher kidney QR activities by 1.32-fold. Additionally,PUL and PIP also caused higher lung QR activities by 1.24-fold and 1.54-fold, respectively. Taken together, we showed that PUL and PIP are bifunctional inducers, capable of inducing both the phase I and phase II enzymes in mice},
 pages = {5--9},
 title = {Pulegone and Piperitone, Essential Oil Components of Lamiaceae Family, Enhance the Activities of Drug-Metabolizing Enzymes},
 year = {2023},
 yomi = {ササキ, ケイコ}
}