{"created":"2023-06-19T07:46:32.825315+00:00","id":412,"links":{},"metadata":{"_buckets":{"deposit":"8dd4c436-1d5e-4f38-bc0f-0a3a7fef6158"},"_deposit":{"created_by":15,"id":"412","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"412"},"status":"published"},"_oai":{"id":"oai:cis.repo.nii.ac.jp:00000412","sets":["3:42"]},"author_link":["449","453","1007","454"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"16","bibliographicPageEnd":"9","bibliographicPageStart":"5","bibliographic_titles":[{"bibliographic_title":"千葉科学大学紀要"},{"bibliographic_title":"The University Bulletin of Chiba Insitute of Science","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of pulegone (PUL) and piperitone (PIP), monoterpene ketones found in the essential oils of Lamiaceae family, on the activities of phase I enzymes (7-ethoxyresorufin O-deethylase (EROD), 7-methoxyresorufin O-demethylase (MROD), and 7-pentoxyresorufin O-depentylase (PROD)) and phase II enzymes (glutathione S-transferase (GST) and quinone reductase (QR)) were investigated. Mice were treated orally with PUL (50-200 mg/kg), and PIP (50-200 mg/kg) once a day for 7 days, and then the hepatic and extrahepatic enzyme activities were analyzed. PUL (200 mg/kg) treatment resulted in significantly higher EROD, PROD, GST, and QR activities by 1.79-fold to 6.33-fold, and PIP (200 mg/kg) treatment caused significantly higher EROD, MROD, PROD, GST, and QR activities by 1.18-fold to 3.69-fold. Moreover, PUL-treated mice showed significantly higher protein levels of GST α and PIP-treated animals had significantly higher protein levels of GST π. Similarly, PUL treatment resulted in significantly higher GST and QR activities in kidney by 1.23-fold and 1.68-fold, respectively; PIP treatment caused significantly higher kidney QR activities by 1.32-fold. Additionally,PUL and PIP also caused higher lung QR activities by 1.24-fold and 1.54-fold, respectively. Taken together, we showed that PUL and PIP are bifunctional inducers, capable of inducing both the phase I and phase II enzymes in mice","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"千葉科学大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1230240X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-2565","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 啓子"},{"creatorName":"ササキ, ケイコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SASAKI, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WADA, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MATUOKA, Koozi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-07"}],"displaytype":"detail","filename":"5-9佐々木啓子（英・原著）.pdf","filesize":[{"value":"616.4 kB"}],"format":"application/pdf","license_note":"copyright (c) 2022 by Chiba Institute of Science ","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5-9佐々木啓子（英・原著）","url":"https://cis.repo.nii.ac.jp/record/412/files/5-9佐々木啓子（英・原著）.pdf"},"version_id":"cb63192d-9efe-4c51-bae3-64201f51099d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pulegone and Piperitone, Essential Oil Components of Lamiaceae Family, Enhance the Activities of Drug-Metabolizing Enzymes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pulegone and Piperitone, Essential Oil Components of Lamiaceae Family, Enhance the Activities of Drug-Metabolizing Enzymes"}]},"item_type_id":"10002","owner":"15","path":["42"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-03-28"},"publish_date":"2023-03-28","publish_status":"0","recid":"412","relation_version_is_last":true,"title":["Pulegone and Piperitone, Essential Oil Components of Lamiaceae Family, Enhance the Activities of Drug-Metabolizing Enzymes"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T07:50:02.866496+00:00"}