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Fetal Vertebral Anomalies Induced by Calcium Channel Blockers in Rats
https://cis.repo.nii.ac.jp/records/337
https://cis.repo.nii.ac.jp/records/33741d00d88-105b-4ded-bb28-b6b1ae510b31
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1-5坂芳樹 (402.2 kB)
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copyright (c) 2020 by Chiba Institute of Science
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-05 | |||||
| タイトル | ||||||
| タイトル | Fetal Vertebral Anomalies Induced by Calcium Channel Blockers in Rats | |||||
| タイトル | ||||||
| タイトル | Fetal Vertebral Anomalies Induced by Calcium Channel Blockers in Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
坂, 芳樹
× 坂, 芳樹× 堀本, 政夫× BAN, Yoshiki× HORIMOTO, Masao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study aimed at examining skeletal anomalies of fetuses induced by verapamil, calcium channel blocker, in rats, and comparing the skeletal morphological features and locations to those by another calcium channel blocker of diltiazem. Verapamil at 30 mg/kg or diltiazem at 90 mg/kg were given by a single intraperitoneal injection to pregnant rats on gestation day 11, and cesarean section was conducted and fetuses were obtained on gestation day 21. Fetal skeletons were stained with Alizarin red S and Alcian blue, and examined for the skeletal anomalies. Verapamil and diltiazem increased the incidences of fetuses with skeletal anomalies in the thoracic, lumbar, sacral or caudal vertebrae and the types of anomalies included absent, fused, misshapen and/or split shapes. The affected vertebrae by verapamil or diltiazem were observed from late number of thoracic vertebrae to early number of caudal vertebrae. These results indicate that verapamil-induced vertebral skeletal anomalies were similar in morphological features and locations to those by diltiazem, suggesting that the fetal vertebral anomalies might be common by basic pharmacological properties of verapamil and diltiazem in rats. Key Words: Calcium channel blocker, Diltiazem, Fetus, Rats, Verapamil, Vertebral anomaly |
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| 書誌情報 |
千葉科学大学紀要 en : The University Bulletin of Chiba Insitute of Science 号 14, p. 1-5, 発行日 2021-03-28 |
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| 出版者 | ||||||
| 出版者 | 千葉科学大学 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2436-2565 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
