{"created":"2023-06-19T07:46:32.134554+00:00","id":396,"links":{},"metadata":{"_buckets":{"deposit":"cfb924a5-1ad6-4fb4-a2f4-2b5546294245"},"_deposit":{"created_by":15,"id":"396","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"396"},"status":"published"},"_oai":{"id":"oai:cis.repo.nii.ac.jp:00000396","sets":["3:35"]},"author_link":["1120","1117","954","1121","1118","1119","1115","947","1116"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15","bibliographicPageEnd":"88","bibliographicPageStart":"83","bibliographic_titles":[{"bibliographic_title":"千葉科学大学紀要"},{"bibliographic_title":"The University Bulletin of Chiba Insitute of Science","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"メチル水銀のような有害化学物質の蓄積や毒性発現に細胞密度が影響を与えるかどうかを明らかにするために、新生仔ラット大脳皮質から調製した神経系細胞を、無血清培地を用いて高密度または低密度で培養し、種々の濃度のメチル水銀をシステイン複合体として曝露し、システインのみを曝露した場合と生細胞数の比較を行った。高密度で培養した場合では、低密度で培養した場合よりも、低濃度のメチル水銀の曝露によって生細胞数の低下が認められ、同じ曝露濃度の場合にはその低下率が大きい傾向を示した。水銀蓄積量は、高密度 で培養した方が低密度培養の場合よりも高い値を示したことから、神経系細胞を高密度で培養すると低密度で培養した場合よりも水銀蓄積量が高くなるため、メチル水銀の影響が強く現れた可能性が考えられる。従って 、神経系細胞へのメチル水銀の蓄積や毒性発現に対して細胞密度が重要な因子の一つであると考えられる。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"千葉科学大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1230240X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-2565","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"足立, 達美"},{"creatorName":"アダチ, タツミ","creatorNameLang":"ja-Kana"},{"creatorName":"Adachi, 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Rats","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["35"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-28"},"publish_date":"2022-03-28","publish_status":"0","recid":"396","relation_version_is_last":true,"title":["新生仔ラット大脳皮質の初代培養神経系細胞におけるメチル水銀の毒性に及ぼす細胞密度の影響"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T07:50:24.433647+00:00"}