@article{oai:cis.repo.nii.ac.jp:00000386,
 author = {SASAKI, Keiko and WADA, Keiji and MATUOKA, Koozi},
 issue = {15},
 journal = {千葉科学大学紀要, The University Bulletin of Chiba Insitute of Science},
 month = {Mar},
 note = {The effects of water-soluble organosulfur compounds, S-methyl-L-cysteine (SMC) and S-methyl-L-cysteine sulfoxide (SMCS) and cycloalliin (Cyc) on the activities of xenobiotic-metabolizing enzyme, glutathione S-transferase (GST) were investigated. Mice were treated orally with SMC (50-200 mg/kg), SMCS (50-200 mg/kg), Cyc (50-200 mg/kg) once a day for 5 days, and then the hepatic and extrahepatic enzyme activities were analyzed. SMC treatment resulted in significantly higher GST activities in liver, small intestine, kidney and brain by 1.1-1,4-fold, and SMCS treatment caused significantly higher GST activities in liver and small intestine and kidney except brain by 1.1-1.3-fold, and Cyc treatment caused higher hepatic and kidney GST activities by 1.3-1.4-fold. The present study has suggested that water-soluble organosulfur compounds SMC, SMCS and Cyc might be partly responsible for the biological effects of onion, such as a reduction in the risk of cancer, and deserves more in-depth research in order to improve human health.},
 pages = {1--5},
 title = {Water-soluble Organosulfur Compounds in Onion Influence the Induction of Glutathione S-Transferase},
 year = {2022}
}