{"created":"2023-06-19T07:46:23.902750+00:00","id":218,"links":{},"metadata":{"_buckets":{"deposit":"e0873813-bcc1-436d-bce0-88c39baa9482"},"_deposit":{"created_by":15,"id":"218","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"218"},"status":"published"},"_oai":{"id":"oai:cis.repo.nii.ac.jp:00000218","sets":["3:21"]},"author_link":["676","782","680","679","856","786","857","855","683","854"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"73","bibliographicPageStart":"67","bibliographic_titles":[{"bibliographic_title":"千葉科学大学紀要"},{"bibliographic_title":"The University Bulletin of Chiba Institute of Science","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"血漿タンパク質は医薬品や内因性物質と血液中で可逆的に結合するため、医薬品などの薬理効果発現や体内動態に影響を与える。そのため血漿タンパク質の大部分を占めるヒト血清アルブミン（HSA）に対する薬物の結合定数の測定は重要である。しかしながら、論文等で報告されている薬物の結合定数には、大きなばらつきがあり、比較することが難しい。この要因の1つとして、測定条件が統一されていないことが挙げられる。本研究では、近年新薬開発における標的タンパク質－治療薬候補薬物の結合定数決定に用いられている高感度型等温滴定型熱量計（Isothermal Titration Calorimeter、ITC）により、HSAと非ステロイド性抗炎症薬であるflurbiprofenとの結合定数へ及ぼす温度、緩衝液濃度、緩衝液の種類、HSA濃度といった測定条件の影響を調査し、測定条件により結合定数が2～3倍変化することを明らかにした。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"千葉科学大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1230240X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1882-3505","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大高, 泰靖"},{"creatorName":"オオタカ, 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Akimasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-30"}],"displaytype":"detail","filename":"067-073_大高先生.pdf","filesize":[{"value":"527.0 kB"}],"format":"application/pdf","license_note":"copyright (c) 2016 by Chiba Institute of Science","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"067-073_大高先生.pdf ","url":"https://cis.repo.nii.ac.jp/record/218/files/067-073_大高先生.pdf"},"version_id":"dd548cff-85c7-4c3c-94b9-5b6a44725e26"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト血清アルブミンへの薬物結合に及ぼす測定条件の影響 : 高感度型等温滴定型熱量計VP-ITCを用いた検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト血清アルブミンへの薬物結合に及ぼす測定条件の影響 : 高感度型等温滴定型熱量計VP-ITCを用いた検討"},{"subitem_title":"Influence of Measurement Conditions on Drug : Plasma Protein Binding Using Sensitive Isothermal Titration Calorimeter VP-ITC","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["21"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-30"},"publish_date":"2017-06-30","publish_status":"0","recid":"218","relation_version_is_last":true,"title":["ヒト血清アルブミンへの薬物結合に及ぼす測定条件の影響 : 高感度型等温滴定型熱量計VP-ITCを用いた検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T07:54:32.151309+00:00"}