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アイテム
3,4,5,4'-Tetramethoxy-cis-Stilbene, a Potent Resveratrol Analog, Inhibits NF-κB Signaling
https://cis.repo.nii.ac.jp/records/2000150
https://cis.repo.nii.ac.jp/records/20001500a20046c-1f27-44ee-9c67-6748e7da983a
| 名前 / ファイル | ライセンス | アクション |
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佐々木 啓子 【原著】3,4,5,4'-Tetramethoxy-cis-Stilbene, a Potent Resveratrol Analog, Inhibits NF-κB Signaling.pdf (780 KB)
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copyright (c)2025 by Chiba Institute of Science
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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| 公開日 | 2026-03-27 | |||||||||||
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| タイトル | 3,4,5,4'-Tetramethoxy-cis-Stilbene, a Potent Resveratrol Analog, Inhibits NF-κB Signaling | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 著者 |
SASAKI, Keiko
× SASAKI, Keiko× MATSUOKA, Koozi
× GOSSLAU, Alexander
× CHEN, Kuang Yu
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Resveratrol (3, 5, 4'-trihydroxy-trans-stibene (R-3), a trihydroxy-trans-stilbene from grape, peanuts and other plants is known to inhibit multi-stage carcinogenesis in animal experiments. Considering its therapeutic potential, we have synthesized a series of resveratrol-based stilbene analogs, including polyhydroxy- and polymethoxy-stilbenes in trans and cis configurations, to check the structure and activity relationship. Among those analogs, we observed that 3,4,5,4’-tetramethoxy-trans-stilbene (MR-4) and 3,4,5,4’-tetramethoxy-cis-stilbene (MC-4) were more potent than the original R-3 in the activity causing growth inhibition of tumor cells. In this relation, NF-kB, a transcription factor, is considered to be involved in the regulation of gene expression for cell growth and apoptosis. Blocking the NF-kB pathway by the polyphenol analogs such as resveratrol would be useful to analyze the target site of NF-kB. Here, we employed a Jurkat human T-cell acute lymphocytic leukemia strain, transfected with NF-𝜅B promoters fused to a GFP reporter gene, to compare the activity of R-3 and cis-resveratrol (C-3), MR-4 or MC-4. Our results herein provide evidence that IkB Kinase (IKK) may be earlier target of the stilbene polyphenols. Particularly, with the IC50 in nanomolar range, MC-4 may be utilized in the future to identify the molecular target of NF-kB signaling and related tumor and inflammatory mechanisms. | |||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
ja : 千葉科学大学紀要 en : The University Bulletin of Chiba Institute of Science 号 19, p. 6-12, ページ数 7, 発行日 2026-03-27 |
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| 出版者 | 千葉科学大学 | |||||||||||
| 言語 | ja | |||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2436-2565 | |||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA1230240X | |||||||||||
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| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| 査読の有無 | Peer reviewed | |||||||||||
