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Developmental toxicity study of 6-aminonicotinamide in mice -Effects of a single treatment during the organogenesis-
https://cis.repo.nii.ac.jp/records/2000149
https://cis.repo.nii.ac.jp/records/20001494a1d84ed-3081-440c-a05f-1e74ad92d2d6
| 名前 / ファイル | ライセンス | アクション |
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坂 芳樹 【原著】 Developmental toxicity study of 6-aminonicotinamide in mice.pdf (277 KB)
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copyright (c)2025 by Chiba Institute of Science
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2026-03-27 | |||||
| タイトル | ||||||
| タイトル | Developmental toxicity study of 6-aminonicotinamide in mice -Effects of a single treatment during the organogenesis- | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
BAN, Yoshiki
× BAN, Yoshiki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study aimed at examining the embryolethality and teratogenic potential by 6-aminonicotinamide (6-AN), and determining the critical period following a single administration during the organogenesis in mice. 6-AN at 15 mg/kg was administered orally to females either on gestation day (GD) 8, 9, 10, 11, 12, 13 or 14, and cesarean section was conducted on GD 18. The uterine implants were classified as live fetus, or resorbed or dead fetus. The live fetuses were weighed and examined for external or skeletal anomalies. There were significant or slight increases in the number of resorptions, dead fetuses or % of postimplantation losses and the corresponding decrease in the number of live fetuses, and significant decreases in live fetal weights in any treatment groups. In the external examination, cleft palate was mainly observed in the GD 9, 10, 11, 12, 13 or 14 treatment groups, and club foot or hindlimb digital anomalies were observed in the GD 9 or 10 treatment groups. In the skeletal examination, the vertebral or hindlimb anomalies were observed in the GD 8, 9 or 10 treatment groups. In conclusion, a single oral administration of 6-AN at 15 mg/kg during the organogenesis clearly revealed that embryolethality and teratogenic potentials of cleft palate, vertebral or hindlimb anomalies, and the critical period of these anomalies were determined GD 9 to 14, GD 8 to 10, or GD 9 to 10, respectively, in this study condition. | |||||
| 言語 | en | |||||
| 書誌情報 |
ja : 千葉科学大学紀要 en : The University Bulletin of Chiba Institute of Science 号 19, p. 1-5, ページ数 5, 発行日 2026-03-27 |
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| 出版者 | ||||||
| 出版者 | 千葉科学大学 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2436-2565 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1230240X | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 査読の有無 | Peer reviewed | |||||
