{"created":"2023-06-19T07:46:22.352762+00:00","id":185,"links":{},"metadata":{"_buckets":{"deposit":"967f57e3-3951-451b-9745-9ebed6aff6b2"},"_deposit":{"created_by":15,"id":"185","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"185"},"status":"published"},"_oai":{"id":"oai:cis.repo.nii.ac.jp:00000185","sets":["3:20"]},"author_link":["672","673","777","778","716","780","666","779","736","781","667","675","719","735"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"74","bibliographicPageStart":"67","bibliographic_titles":[{"bibliographic_title":"千葉科学大学紀要"},{"bibliographic_title":"The University Bulletin of Chiba Institute of Science","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"古来から天然の薬として服用されてきた有機ゲルマニウムは、角層中のコーニファイドエンベロープ形成や細胞間脂質を構成するセラミド合成促進などの効果が近年見出され、皮膚への有効性が期待されている。昨年、我々は有機ゲルマニウムを配合したクリームを皮膚に塗布した際の角層水分量と経表皮水分蒸散量（TEWL）の変化について調べ、有機ゲルマニウムに角層の保湿性を向上する傾向があることを報告した。\n本研究では、剤型をクリームから化粧水に変更し、市販の有機ゲルマニウム含有化粧水と含有されない化粧水を用いて角層水分量、TEWL、皮膚粘弾性、および皮膚色の変化から皮膚への塗布効果を調べた。4週間の連用塗布によって、有機ゲルマニウム配合化粧水は未配合化粧水に比べて有意に角層水分量は増加したが、その他の評価項目に関しては著しい差は見られなかった。また、本研究では、この角層水分量の増加に対して表皮中のフィラグリンから産生されるピロリドンカルボン酸量との関係について調べた。化粧水中の有機ゲルマニウムの有無に関係なく皮膚の保湿能に関係するピロリドンカルボン酸量は変化しておらず、有機ゲルマニウム配合化粧水の高い保湿機能が天然保湿成分の量的変化に関与していないことが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Organogermanium, which has been utilized as a natural medicine from acient times, was found out recently to promote the formation, maturation of cornified envelope as well as the synthesis of ceramide which is one of the main constituents to compose the stratum corneum (SC) lipid layers of the skin, leading to our expectation that organogermanium may exhibit effectiveness on the skin conditions. Our latest investigation by measuring water content of SC and transepidermal water loss (TEWL) revealed that the application of organogermanium tends to improve the hydration state of the SC.\n\nInstead of the cream formulation that had been used in our previous clinical test, in the present study we investigated the effect of organogermanium contained in the lotion on the skin conditions by measuring the water content of SC, TEWL, as well as skin viscoelasticity and skin colour. Four weeks continuous application of the lotion containing organogermanium significantly increased water content of SC in comparison with that without organogermanium, while the other measured skin properties almost remained unchanged. In addition, neither the lotion with nor that without organogermanium affected the amount of pyrrolidone carboxylic acid (PCA) in the SC that can relate to the hydration state of the stratum corneum. These obtained findings suggest that the increase in water content of SC by the repeated applications of the organogermanium lotion is not related to the changes in the PCA level in SC.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"千葉科学大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1230240X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1882-3505","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山下, 裕司"},{"creatorName":"ヤマシタ, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"735","nameIdentifierScheme":"WEKO"},{"nameIdentifier":" 9000291613869","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/ 9000291613869"}]},{"creatorNames":[{"creatorName":"山崎, 舞"},{"creatorName":"ヤマサキ, マイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"667","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 真綾"},{"creatorName":"スズキ, マアヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"萩原, 宏美"},{"creatorName":"ハギワラ, ヒロミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"716","nameIdentifierScheme":"WEKO"},{"nameIdentifier":" 9000291613775","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/ 9000291613775"}]},{"creatorNames":[{"creatorName":"田上, 八郎"},{"creatorName":"タガミ, ハチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"719","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003756054","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003756054"}]},{"creatorNames":[{"creatorName":"平尾, 哲二"},{"creatorName":"ヒラオ, テツジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂本, 一民"},{"creatorName":"サカモト, カズタミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"736","nameIdentifierScheme":"WEKO"},{"nameIdentifier":" 9000291613870","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/ 9000291613870"}]},{"creatorNames":[{"creatorName":"YAMASHITA, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"666","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000238286313","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000238286313"}]},{"creatorNames":[{"creatorName":"Yamasaki, Mai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SUZUKI, Maaya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAGIWARA, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAGAMI, Hachiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIRAO, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAKAMOTO, Kazutami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000238286314","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000238286314"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-06-03"}],"displaytype":"detail","filename":"067-074-山下先生.pdf","filesize":[{"value":"32.9 MB"}],"format":"application/pdf","license_note":"copyright (c) 2015 by Chiba Institute of Science","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"067-074-山下先生.pdf ","url":"https://cis.repo.nii.ac.jp/record/185/files/067-074-山下先生.pdf"},"version_id":"996dd229-0a3a-416c-80ac-31ad8fc7ef8f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"有機ゲルマニウム配合化粧料の皮膚保湿効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"有機ゲルマニウム配合化粧料の皮膚保湿効果"},{"subitem_title":"Moisturizing Effect of The Cosmetics Containing Organogermanium on Skin","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["20"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-06-03"},"publish_date":"2016-06-03","publish_status":"0","recid":"185","relation_version_is_last":true,"title":["有機ゲルマニウム配合化粧料の皮膚保湿効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T07:55:30.752658+00:00"}