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Developmental toxicity study of immunosuppressive compound, azathioprine in rats Effects of a single treatment during the organogenesis
https://cis.repo.nii.ac.jp/records/411
https://cis.repo.nii.ac.jp/records/411b78d611e-b911-4185-a285-68e9dbfa2799
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1-4坂芳樹（英・原著） (333.3 kB)
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copyright (c) 2022 by Chiba Institute of Science
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-03-28 | |||||
| タイトル | ||||||
| タイトル | Developmental toxicity study of immunosuppressive compound, azathioprine in rats Effects of a single treatment during the organogenesis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Azathioprine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Critical period | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Development | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Rats | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Toxicity | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
BAN, Yoshiki
× BAN, Yoshiki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study aimed at examining the embryolethality and teratogenic potential by azathioprine, and determining the critical period of effects by a single treatment during the organogenesis in rats. Azathioprine at 40 mg/kg was administered orally to females either on gestation day (GD) 7, 8, 9, 10, 11, 12, 13 or 14 and cesarean section was conducted on GD 21. The uterine implants were classified as live fetus, or resorbed or dead fetus. The live fetuses were weighed and examined for external or skeletal anomalies. There were significant increases in % of postimplantation losses and the corresponding decreases in number of live fetuses in the GD 7, 8, 9 and 10 treatment groups, and the critical period of fetal deaths were determined from GD 7 to 10. In the surviving fetuses, there were decreases in fetal body weights in the GD 9, 11 and 12 treatment groups. No treatment-related external orskeletal malformations were bserved in any treatment groups. In conclusion, these were embryolethality with stage specificity fromGD 7 to 10 but were no teratogenic potentials in this experimental conditions. | |||||
| bibliographic_information |
千葉科学大学紀要 en : The University Bulletin of Chiba Insitute of Science 号 16, p. 1-4, 発行日 2023-03-28 |
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| 出版者 | ||||||
| 出版者 | 千葉科学大学 | |||||
| item_10002_source_id_9 | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2436-2565 | |||||
| item_10002_source_id_11 | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1230240X | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
